Generation of an induced pluripotent stem cell line, IBMS-iPSC-014-05, from a female autosomal dominant polycystic kidney disease patient carrying a common mutation of R803X in PKD2

Autosomal dominant polycystic kidney disease (ADPKD) is one of the most commonly inherited forms of polycystic kidney disease, and is characterized by the growth of numerous cysts in both kidneys.Here we generated an induced pluripotent stem cell (iPSC) line from the VOLUMIZER peripheral blood mononuclear cells (PBMCs) of a 63-year-old female ADPKD

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NOD/scid IL-2Rgnull mice: a preclinical model system to evaluate human dendritic cell-based vaccine strategies in vivo

Abstract Background To date very few systems have been described for preclinical investigations of human cellular therapeutics in vivo.However, the ability to carry out comparisons of new cellular vaccines in vivo would be of substantial interest for design of clinical studies.Here we describe a humanized mouse model to assess the efficacy of vario

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